Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F14%3A64302" target="_blank" >RIV/60460709:41210/14:64302 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12520/14:43886843

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo

Original language description

The fungicide vinclozolin (VZ) is in use globally and known to disrupt reproductive function in male. The present study tested the hypothesis that VZ disrupts testicular function in goldfish (Carassius auratus) by affecting brain-pituitary-testis axis. Goldfish were exposed to 100, 400 and 800 ?g/L VZ and 5 ?g/L 17ß-estradiol (E2) for comparison. In VZ treated goldfish, 11-ketotesteosterone (11-KT) secretion was changed depending on dose and duration period of treatment. Following 7 days of exposure, 11-KT was decreased in goldfish exposed to 800 ?g/L VZ, while it was increased in goldfish exposed to 100 ?g/L VZ after 30 days of exposure. Circulating E2 level was unchanged in VZ treated goldfish, however the E2/11-KT ratio was increased in a dose-related manner. In E2 treated goldfish, circulatory 11-KT and E2 levels were decreased and increased respectively, which resulted in an increase in the E2/11-KT ratio. Exposure to VZ at 100 ?g/L caused a significant increase in the circulatory

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GL - Fishery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

AQUATIC TOXICOLOGY

ISSN

0166-445X

e-ISSN

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Volume of the periodical

155

Issue of the periodical within the volume

N

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

11

Pages from-to

73-83

UT code for WoS article

000342245300009

EID of the result in the Scopus database

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