Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F14%3A43886816" target="_blank" >RIV/60076658:12520/14:43886816 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1532045614000106" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1532045614000106</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cbpc.2014.02.001" target="_blank" >10.1016/j.cbpc.2014.02.001</a>
Alternative languages
Result language
angličtina
Original language name
Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae
Original language description
Cadmium is a heavy metal abundant in the environment that can induce endocrine disorder and toxicity in aquatic organisms at low levels. However, its effects on the thyroid system in fish are still unclear. In this study, the thyroid hormone (TH) levelsand the expression profiles of genes related to hypothalamic-pituitary-thyroid (HPT) axis, including corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5),thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta), were determined in whole body of Chinese rare minnow (Gobiogpris rams) larvae after exposure to different levels of Cd2+ (0, 0.5 and 2.5 mg/L) for4 days. And the 96-h lethal concentration of Cd2+ on rare minnow larvae was determined as 2.59 mg/L. The results showed that crh, slc5a5, tg and tsh beta mRNA levels were significantly up-regulated in the larvae, but the gene expression o
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GL - Fishery
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Comparative Biochemistry and Physiology C - Toxicology and Pharmacology
ISSN
1532-0456
e-ISSN
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Volume of the periodical
161
Issue of the periodical within the volume
April
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
53-57
UT code for WoS article
000333792400008
EID of the result in the Scopus database
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