Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F14%3A43886815" target="_blank" >RIV/60076658:12520/14:43886815 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1382668914001562" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1382668914001562</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.etap.2014.07.002" target="_blank" >10.1016/j.etap.2014.07.002</a>

Result language
angličtina
Original language name
Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride
Original language description
Mercury is a prominent environmental contaminant that causes endocrine disorder to human and other organisms. But little is known about the response of the thyroid functions and hypothalamic-pituitary-thyroid (HPT) axis to mercury in teleosts and the fewstudies that are available have not yielded consistent results. In this study, expression profiles of corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta) genes were determined in whole-body of Chinese rare minnow (Gobiocypris Torus) larvae after exposure to different levels of Hg2+ (0, 0.1 and 0.3 mg/l) for 4 days, as well as the thyroid hormones (THs) levels. Moreover, the 96-h lethal concentration of Hg2+ on rare minnow larvae was determined as 0.32 mg/l. The results showed that crh, tg, tr alpha and tr beta mRNA levels were signi
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GL - Fishery
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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