Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F16%3A43890374" target="_blank" >RIV/60076658:12520/16:43890374 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/tox.22042/abstract;jsessionid=1B9AFF16FDAE8F7D78802C2809B9412A.f01t04" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/tox.22042/abstract;jsessionid=1B9AFF16FDAE8F7D78802C2809B9412A.f01t04</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/tox.22042" target="_blank" >10.1002/tox.22042</a>

Result language
angličtina
Original language name
Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin
Original language description
Tributyltin (TBT), as antifouling paints, is widely present in aquatic environment, but little is known regarding the toxicity of TBT on fish brain. In this study, the effects of exposure to TBT on the antioxidant defense system, Na+-K+-ATPase activity, neurological enzymes activity and Hsp 70 protein level in brain of juvenile common carp (Cyprinus carpio) were studied. Fish were exposed to sublethal concentrations of TBT (5, 10 and 20 g/L) for 7 days. Based on the results, with increasing concentrations of TBT, oxidative stress was apparent as reflected by the significant higher levels of oxidative indices, as well as the significant inhibition of all antioxidant enzymes activities. Besides, the activities of Acetylcholinesterase (AChE), Monoamine oxidases (MAO) and Na+-K+-ATPase were significantly inhibited after exposure to TBT with higher concentrations. In addition, the levels of Hsp 70 protein were evaluated under TBT stress with dose-depended manner. These results suggest that selected physiological responses in fish brain could be used as potential biomarkers for monitoring residual organotin compounds present in aquatic environment. (c) 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 278-284, 2016.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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