Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F17%3A43891422" target="_blank" >RIV/60076658:12520/17:43891422 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0300483X16302931" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0300483X16302931</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tox.2016.11.014" target="_blank" >10.1016/j.tox.2016.11.014</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450
Original language description
Cytochrome P450 proteins (CYP450s) are present in most domains of life and play a critical role in the metabolism of endogenous compounds and xenobiotics. The effects of exposure to xenobiotics depend heavily on the expression and activity of drug-metabolizing CYP450s, which is determined by species, genetic background, age, gender, diet, and exposure to environmental pollutants. Numerous reports have investigated the role of different vertebrate CYP450s in xenobiotic metabolism. Model organisms provide powerful experimental tools to investigate Phase I metabolism. The aim of the present review is to compare the existing data on human CYP450 proteins (1-3 families) with those found in pigs, mice, and fish. We will highlight differences and similarities and identify research gaps which need to be addressed in order to use these species as models that mimic human traits. Moreover, we will discuss the roles of nuclear receptors in the cellular regulation of CYP450 expression in select organisms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology
ISSN
0300-483X
e-ISSN
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Volume of the periodical
375
Issue of the periodical within the volume
January
Country of publishing house
IE - IRELAND
Number of pages
18
Pages from-to
10-27
UT code for WoS article
000392681200002
EID of the result in the Scopus database
2-s2.0-85002489620