Efficacy and toxicity of praziquantel in helminth-infected barbel (Barbus barbus L.)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F18%3A43897080" target="_blank" >RIV/60076658:12520/18:43897080 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/jfd.12764/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jfd.12764/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jfd.12764" target="_blank" >10.1111/jfd.12764</a>

Result language
angličtina
Original language name
Efficacy and toxicity of praziquantel in helminth-infected barbel (Barbus barbus L.)
Original language description
This study evaluated efficacy and toxicity of the pyrazinoisoquinoline anthelmintic praziquantel (PZQ) in barbel infected with metacercariae of Diplostomum spathaceum and adult Pomphorhynchus laevis, and assessed antioxidant biomarkers and the lipid peroxidation response in juvenile barbel post-treatment. The estimated 96-hr LC50 of PZQ was 28.6mg/L. For evaluation of efficacy, barbel naturally infected with D.spathaceum were exposed to a 10 and 20mg/L PZQ 4-day bath treatment. Both concentrations were 100% effective against D.spathaceum and significantly (p<.01) affected the activity of catalase, superoxide dismutase, glutathione reductase and glutathione-S-transferase as well as levels of reduced glutathione in liver and muscle. The efficacy of orally administered PZQ was assessed in adult barbel naturally infected with P.laevis. Fish were administered 10, 30 and 50mg/kg of body weight and examined via gut dissection after 6days. The 50mg/kg dose significantly decreased the intensity of infection. Praziquantel is a feasible bath treatment for barbel infected with D.spathaceum and has potential for oral treatment of broodfish infected with P.laevis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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