Delivery of Iron Oxide Nanoparticles into Primordial Germ Cells in Sturgeon
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F19%3A43899293" target="_blank" >RIV/60076658:12520/19:43899293 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2218-273X/9/8/333" target="_blank" >https://www.mdpi.com/2218-273X/9/8/333</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biom9080333" target="_blank" >10.3390/biom9080333</a>
Alternative languages
Result language
angličtina
Original language name
Delivery of Iron Oxide Nanoparticles into Primordial Germ Cells in Sturgeon
Original language description
Nanoparticles are finding increasing applications in diagnostics, imaging and therapeutics in medicine. Iron oxide nanoparticles (IONs) have received significant interest of scientific community due to their distinctive properties. For the first time, we have delivered IONs into germ cells in any species. Our results showed that sturgeon primordial germ cells (PGCs) delivered with IONs could be detected until seven days post fertilization (dpf) under fluorescent microscope and at 22 dpf by micro-CT. Delivery of IONs into cells could be helpful for studying germ cell biology and the improvement of germ cell-based bio-technologies as isolation of PGCs using magnetic activated cell sorting or application of hyperthermia for a host sterilization purpose. Intriguingly, in our study, we did not find any toxic effects of IONs on the survival and hatching rates of sturgeon embryos when compared with embryos injected with FITC-dextran only.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomolecules
ISSN
2218-273X
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
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UT code for WoS article
000484457600038
EID of the result in the Scopus database
2-s2.0-85070681712