Using fish spermatozoa in in vitro toxicity tests: A potential toxicology tool
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F21%3A43902630" target="_blank" >RIV/60076658:12520/21:43902630 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.aquaculture.2021.736647" target="_blank" >https://doi.org/10.1016/j.aquaculture.2021.736647</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aquaculture.2021.736647" target="_blank" >10.1016/j.aquaculture.2021.736647</a>
Alternative languages
Result language
angličtina
Original language name
Using fish spermatozoa in in vitro toxicity tests: A potential toxicology tool
Original language description
In recent years, the development and implementation of new in vitro techniques for ecotoxicology and environmental risk assessment has become a priority; however, the current data indicate a lack of standardization in available in vitro sperm tests. In this review, we describe the main approaches currently used for in vitro toxicity testing of fish spermatozoa. Though fish species show huge diversity in their reproductive strategies, most are external fertilizers. Fish spermatozoa are highly specialized, transcriptionally inactive cells that become motile only upon spawning in the aqueous environment. Here, we suggest that they could become a useful toxicology tool because of their simplicity and availability. Indeed, fish spermatozoa are a promising model for genotoxicity testing, since parental exposure to genotoxicants, both in vivo and in vitro, affect embryo development. In aquaculture practice it means that evaluation of spermatozoa DNA damage could help in predicting embryo quality. Fish spermatozoa could also be useful for the study on nongenomic mechanisms of toxicity, such as the effects of xenobiotics on protein posttranslational modifications. Nevertheless, we conclude that further studies on fish spermatozoa are required to establish a clear correlation between in vitro and in vivo toxicities.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10617 - Marine biology, freshwater biology, limnology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aquaculture
ISSN
0044-8486
e-ISSN
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Volume of the periodical
539
Issue of the periodical within the volume
neuveden
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
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UT code for WoS article
000647594200008
EID of the result in the Scopus database
2-s2.0-85103328129