Use of all-male triploid population of zebrafish (Danio rerio) for evaluation of 17α-ethinylestradiol effects

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F22%3A43905735" target="_blank" >RIV/60076658:12520/22:43905735 - isvavai.cz</a>
Result on the web
<a href="https://www.nel.edu/use-of-all-male-triploid-population-of-zebrafish-danio-rerio-for-evaluation-of-17-ethinylestradiol-effects-2872/" target="_blank" >https://www.nel.edu/use-of-all-male-triploid-population-of-zebrafish-danio-rerio-for-evaluation-of-17-ethinylestradiol-effects-2872/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Use of all-male triploid population of zebrafish (Danio rerio) for evaluation of 17α-ethinylestradiol effects
Original language description
OBJECTIVES: We tested the toxicity of ethinylestradiol, a semisynthetic estrogen used in oral contraceptives, on all-male triploid zebrafish using commercial feeds and three different doses concentrations. We aimed to determine whether ethinylestradiol peroral administration resulted in vitellogenin production and whether all-male triploid zebrafish could serve as a model species for xenoestrogen testing. METHODS: The actual concentrations of 17α-ethinylestradiol were 0.0035 (low); 0.0315 (medium) and 0.365 (high) µg/g. Positive control represented commercial feeds containing 0.0465 µg/g of β-estradiol. The experiment lasted 8 weeks. RESULTS: Our results indicate that 17α-ethinylestradiol consumption does induce vitellogenin production in triploid zebrafish. CONCLUSIONS: The simple presence of vitellogenin is a definite symptom indicative of the potential for such changes due to the action of estrogenic substances. As such, this experiment has shown that the use of all-male triploid zebrafish populations, rather than the mixed-sex populations of other species previously used, could serve as a suitable alternative model population for controlled testing of the effects of xenoestrogens on fish.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10617 - Marine biology, freshwater biology, limnology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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