Use of all-male triploid population of zebrafish (Danio rerio) for evaluation of 17 alpha-ethinylestradiol effects

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43923044" target="_blank" >RIV/62156489:43210/22:43923044 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14160/22:00128945 RIV/62157124:16270/22:43880386
Result on the web
<a href="https://www.nel.edu/userfiles/articlesnew/1674499217_43_5_weiserova_281-pdf.pdf" target="_blank" >https://www.nel.edu/userfiles/articlesnew/1674499217_43_5_weiserova_281-pdf.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Use of all-male triploid population of zebrafish (Danio rerio) for evaluation of 17 alpha-ethinylestradiol effects
Original language description
Objectives: We tested the toxicity of ethinylestradiol, a semisynthetic estrogen used in oral contraceptives, on all-male triploid zebrafish using commercial feeds and three different doses concentrations. We aimed to determine whether ethinylestradiol peroral administration resulted in vitellogenin production and whether all-male triploid zebrafish could serve as a model species for xenoestrogen testing. Methods: The actual concentrations of 17α-ethinylestradiol were 0.0035 (low); 0.0315 (medium) and 0.365 (high) µg/g. Positive control represented commercial feeds containing 0.0465 µg/g of β-estradiol. The experiment lasted 8 weeks. Results: Our results indicate that 17α-ethinylestradiol consumption does induce vitellogenin production in triploid zebrafish. Conclusions: The simple presence of vitellogenin is a definite symptom indicative of the potential for such changes due to the action of estrogenic substances. As such, this experiment has shown that the use of all-male triploid zebrafish populations, rather than the mixed-sex populations of other species previously used, could serve as a suitable alternative model population for controlled testing of the effects of xenoestrogens on fish.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science

Project
<a href="/en/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Sustainable production of healthy fish in various aquaculture systems - PROFISH</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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