Cause and consequence of heterogeneity in human mesenchymal stem cells: Challenges in clinical application
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F24%3A43909073" target="_blank" >RIV/60076658:12520/24:43909073 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.prp.2024.155354" target="_blank" >https://doi.org/10.1016/j.prp.2024.155354</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.prp.2024.155354" target="_blank" >10.1016/j.prp.2024.155354</a>
Alternative languages
Result language
angličtina
Original language name
Cause and consequence of heterogeneity in human mesenchymal stem cells: Challenges in clinical application
Original language description
Human mesenchymal stem cells (hMSCs) are mesoderm-derived adult stem cells with self-proliferation capacity, pluripotent differentiation potency, and excellent histocompatibility. These advantages make hMSCs a promising tool in clinical application. However, the majority of clinical trials using hMSC therapy for diverse human diseases do not achieve expectations, despite the prospective pre-clinical outcomes in animal models. This is partly attributable to the intrinsic heterogeneity of hMSCs. In this review, the cause of heterogeneity in hMSCs is systematically discussed at multiple levels, including isolation methods, cultural conditions, donor-to-donor variation, tissue sources, intra-tissue subpopulations, etc. Additionally, the effect of hMSCs heterogeneity on the contrary role in tumor progression and immunomodulation is also discussed. The attempts to understand the cellular heterogeneity of hMSCs and its consequences are important in supporting and improving therapeutic strategies for hMSCs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30401 - Health-related biotechnology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pathology Research and Practice
ISSN
0344-0338
e-ISSN
1618-0631
Volume of the periodical
260
Issue of the periodical within the volume
neuvedeno
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
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UT code for WoS article
001253387600001
EID of the result in the Scopus database
2-s2.0-85195549935