Coenzyme Q10 mitigates high-fat-diet-induced hepatic steatosis in spotted bass (Lateolabrax maculatus) through modulating mitochondrial function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F25%3A43909714" target="_blank" >RIV/60076658:12520/25:43909714 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1017/S0007114525000637" target="_blank" >https://doi.org/10.1017/S0007114525000637</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S0007114525000637" target="_blank" >10.1017/S0007114525000637</a>

Result language

angličtina

Original language name

Coenzyme Q10 mitigates high-fat-diet-induced hepatic steatosis in spotted bass (Lateolabrax maculatus) through modulating mitochondrial function

Original language description

This study elucidated the impacts of coenzyme Q10 (COQ10) supplementation in a high-fat diet (HFD) on growth, lipid metabolism and mitochondrial function in spotted seabass (Lateolabrax maculatus). Totally five diets were formulated: a diet with normal fat content (11 % lipid, NFD), a HFD (17 % lipid) and three additional diets by supplementing 5, 20 or 80 mg/kg of COQ10 to the HFD. After an 8-week culture period, samples were collected and analysed. The results demonstrated that COQ10 inclusion prevented the HFD-induced deterioration of growth performance and feed utilisation. COQ10 alleviated the deposition of saturated fatty acids following HFD intake and promoted the assimilation of n-3 and n-6 PUFA. Moreover, COQ10 administration inhibited the surge in serum transaminase activity and reduced hepatic lipid content following HFD ingestion, which was consistent with the results of oil red O staining. In addition, HFD feeding led to reduced hepatic citrate synthase and succinate dehydrogenase activities and decreased ATP content. Notably, COQ10 administration improved these indices and up-regulated the expression of mitochondrial biogenesis-related genes (pgc-1 alpha, pgc-1 beta, nrf-1, tfam) and autophagy-related genes (pink1, mul1, atg5). In summary, supplementing 20-80 mg/kg of COQ10 in the HFD promoted growth performance, alleviated hepatic fat accumulation and enhanced liver mitochondrial function in spotted seabass.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40103 - Fishery

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British Journal of Nutrition

ISSN

0007-1145

e-ISSN

1475-2662

Volume of the periodical

133

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

1032-1046

UT code for WoS article

001477485200001

EID of the result in the Scopus database

2-s2.0-105001860688