Acquisition of neural crest promoted thyroid evolution from chordate endostyle
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F25%3A43910047" target="_blank" >RIV/60076658:12520/25:43910047 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10500906
Result on the web
<a href="https://www.science.org/doi/full/10.1126/sciadv.adv2657" target="_blank" >https://www.science.org/doi/full/10.1126/sciadv.adv2657</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.adv2657" target="_blank" >10.1126/sciadv.adv2657</a>
Alternative languages
Result language
angličtina
Original language name
Acquisition of neural crest promoted thyroid evolution from chordate endostyle
Original language description
The endostyle is an endodermal organ unique to nonvertebrate chordates except for lamprey larvae, where it serves as forerunner to the adult thyroid. Here, we examine whether the acquisition of neural crest in the vertebrate lineage played a role in the elaboration of the endostyle. CM-DiI lineage tracing reveals a neural crest contribution to the endostyle, and CRISPR-Cas9 mutagenesis of key neural crest genes causes endostyle defects including formation of a single rather than bilobed structure. RNA sequencing reveals gene profiles characteristic of embryonic neural crest cells and Schwann cell precursors in the developing endostyle. Contrasting with the prevailing view that the endostyle is an endoderm-derived organ, we propose that the acquisition of the neural crest played a critical step in promoting thyroid evolution from chordate endostyle.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Advances
ISSN
2375-2548
e-ISSN
2375-2548
Volume of the periodical
11
Issue of the periodical within the volume
32
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
nestránkováno
UT code for WoS article
001545562900013
EID of the result in the Scopus database
2-s2.0-105013075655