Evaluation of targeted and high-resolution mass spectrometry methods for environmental monitoring of pharmaceuticals

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F25%3A43910055" target="_blank" >RIV/60076658:12520/25:43910055 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.mex.2025.103666" target="_blank" >https://doi.org/10.1016/j.mex.2025.103666</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mex.2025.103666" target="_blank" >10.1016/j.mex.2025.103666</a>

Result language
angličtina
Original language name
Evaluation of targeted and high-resolution mass spectrometry methods for environmental monitoring of pharmaceuticals
Original language description
This study presents a comparison of three mass spectrometry-based analytical approaches-targeted tandem mass spectrometry (MS/MS), high-resolution full scan (HRFS), and data-independent acquisition (DIA)-for the quantification and screening of 74 pharmaceuticals across four environmental water matrices: tap water, river water, and influent and effluent wastewater. The methods were validated in terms of limits of quantification (LOQ), trueness, precision, and matrix effects. MS/MS exhibited the best overall performance, achieving the lowest LOQs (median 0.54 ng/L), highest trueness (median 101 %), and minimal matrix effects, confirming its suitability for routine regulatory monitoring. HRFS and DIA, while showing higher LOQs and variability, provided broader screening capabilities with acceptable trueness for 63 % and 81 % of compounds, respectively, and enabled retrospective data analysis. The methods were applied to real samples from the Zivn & yacute; Stream in the Czech Republic to determine pharmaceutical contamination downstream of a wastewater treatment plant (WWTP).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
<a href="/en/project/GA22-03754S" target="_blank" >GA22-03754S: From brain to sperm: how psychoactive pollutants can affect fish sperm function.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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