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The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F06%3A00048924" target="_blank" >RIV/60077344:_____/06:00048924 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12310/06:00006898

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei

  • Original language description

    MRP1 and MRP2 are multifunctional mitochondrial RNA-binding proteins with a regulatory role in RNA editing and putative role(s) in RNA processing in Trypanosoma brucei. Silencing of MRP1 and/or MRP2 by RNA interference affected the assembly and functionality of respiratory complexes. The absence of several subunits of complexes I, III and IV resulted in their disintegration and subsequent decrease of specific activities and also caused a significant decrease of membrane potential. The overall respiration in the interfered cells decreased by only about 20%, since the trypanosome alternative oxidase effectively replaced the missing cytochromes and became the principal terminal oxidase.

  • Czech name

    Vliv potlačení mitochondriálních RNA-vážících proteinů MRP1 a MRP2 na dýchací komplexy procyklického stádia Trypanosoma brucei

  • Czech description

    MRP1 a MRP2 jsou multifunkční, mitochondriální RNA-vážící proteiny s regulační rolí v editování RNA a možnou rolí ve zpracování RNA u Trypanosoma brucei. Umlčení genů pro MRP1 a/nebo MRP2 metodou interference RNA ovlivnilo skládání a funkčnost dýchacíchkomplexů. Absence několika podjednotek komplexů I, III a IV vyústila v jejich desintegraci a následný pokles specifických aktivit a rovněž způsobila signifikantní pokles membránového potenciálu. Celková respirace v ovlivněných buňkách poklesla pouze o 20%, jelikož trypanosomí alternativní oxidáza efektivně nahradila chybějící cytochromy a stala se hlavní koncovou oxidázou.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular and Biochemical Parasitology

  • ISSN

    0166-6851

  • e-ISSN

  • Volume of the periodical

    149

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    9

  • Pages from-to

    65-73

  • UT code for WoS article

  • EID of the result in the Scopus database