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Is the titer of adipokinetic peptides in Leptinotarsa decemlineata fed on genetically modified potatoes increased by oxidative stress?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F07%3A00081474" target="_blank" >RIV/60077344:_____/07:00081474 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Is the titer of adipokinetic peptides in Leptinotarsa decemlineata fed on genetically modified potatoes increased by oxidative stress?

  • Original language description

    The level of adipokinetic hormones (AKHs) (Peram-CAH-I and II) in the corpora cardiaca and the hemolymph of Leptinotarsa decemlineata enormously increases in the adults fed on genetically modified potatoes containing either GNA lectin or Cry 3Aa toxin concomitant with increased oxidative stress in gut tissues. A similar enhancement of the AKH titer is achieved when the adults are injected with paraquat that evokes oxidative stress. On the other hand, an injection of exogenous AKH reduces oxidative stress bio-markers in the hemolymph by reducing protein carbonyls and enhancing reduced glutathione levels. These facts indicate that there is a feed-back regulation between an oxidative stressor action and the level of AKH in the insect body, and that AKHs might be involved in the activation of an antioxidant protection mechanism. These results, are to our knowledge, the first evidence for the involvement of AKHs in oxidative stress mitigation, in addition to a plethora of other roles.

  • Czech name

    Je hladina adipokinetických peptidů u Leptinotarsa decemlineata živené geneticky modifikovanými bramborami zvýšena oxidačním stresem?

  • Czech description

    Hladina adipokinetických hormonů (AKH) se v corpora cardiaca i hemolymfě u Leptinotarsa decemlineata významně zvyšuje, pokud jsou dospělci krmeni geneticky modifikovanými bramborami obsahujícími GNA lektin nebo Cry 3Aa toxin, které zároveň zvyšují oxidační stres ve střevě. Podobný účinek má i herbicid paraquat, který se běžně používá na navození podmínek oxidačního stresu. Na druhé straně injekce AKH snižuje biomarkery oxidačního strese v hmyzím těle. Tato fakta naznačují, že existuje zpětná vazba mezipůsobením oxidačních stresorů a hladinou AKH. Zdá se tedy, že AKH hraje roli v eliminaci následků oxidačního stresu u hmyzu.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Peptides

  • ISSN

    0196-9781

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    974-980

  • UT code for WoS article

  • EID of the result in the Scopus database