Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F07%3A00087514" target="_blank" >RIV/60077344:_____/07:00087514 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy
Original language description
We have conducted a multifactorial genetic analysis of the Leishmania donovani complex that includes DNA sequences of protein-coding genes as well as noncoding segments, microsatellites, restriction-fragment length polymorphisms, and randomly amplified polymorphic DNAs, for a total of approximate to 18,000 characters for each of 25 geographically representative strains. Genotype is strongly correlated with geographical (continental) origin, but not with current taxonomy or clinical outcome. We propose anew taxonomy, in which Leishmania infantum and L. donovani are the only recognized species of the L. donovani complex, and we present an evolutionary hypothesis for the origin and dispersal of the species.
Czech name
Evoluční a geografická historie komplexu Leishmania donovani a revize současné taxonomie
Czech description
Provedli jsme multifaktoriální genetickou analýzu komplexu Leishmania donovani, která zahrnuje sekvenování protein kódujících genů a nekódujících úseků, mikrosatelity, RFLP a RAPD data. Celkem bylo hodnoceno 18000 znaků pro každý z 25 kmenů. Genotyp silně koreluje s geografickým původem, ovšem nikoliv se současnou taxonomií. Navrhli jsme novou taxonomii komplexu zahrnující pouze druhy L. infantum a L. donovani a zároveň jsme navrhli hypotézu vzniku tohoto komplexu a rozšíření těchto druhů.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>R - Projekt Ramcoveho programu EK
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
104
Issue of the periodical within the volume
22
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
9375-9380
UT code for WoS article
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EID of the result in the Scopus database
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