The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F08%3A00318325" target="_blank" >RIV/60077344:_____/08:00318325 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei
Original language description
Frataxin is a conserved mitochondrial protein, almost universally present in prokaryotes and eukaryotes, where it is implicated in Fe-S cluster assembly and several other processes. Here we show that frataxins from the diatom Thalassiosira pseudonana andthe plant Arabidopsis thaliana are efficiently targeted and processed in the mitochondrion of the evolutionary distant excavate kinetoplastid flagellate Trypanosoma brucei. Moreover, both heterologous frataxins are able to rescue a lethal deficiency forT. brucei frataxin.
Czech name
Import a funkce rozsivkového a rostlinného frataxinu v mitochondrii Trypanosoma brucei
Czech description
Frataxin je konzervovaný mitochondriální protein, všudypřítomný u prokaryot a eukaryot, kde se zúčastňuje tvorby Fe-S klasterů a dalších procesů. V této práci ukazujeme, že frataxin z rozsivky Thalassiosira pseudonana a rostliny Arabidopsis thaliana je efektivně vnášen a upravován v mitochondrii evolučně vzdáleného kinetoplastidového bičíkovce Trypanosoma brucei. Navíc byly oba heterologní frataxiny schopny zachránit smrtelnou deficienci frataxinu v T. brucei.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Biochemical Parasitology
ISSN
0166-6851
e-ISSN
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Volume of the periodical
162
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
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UT code for WoS article
000260547900011
EID of the result in the Scopus database
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