IrAM?An .alpha.2-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00327045" target="_blank" >RIV/60077344:_____/09:00327045 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/09:00010576 RIV/60077344:_____/09:00358930
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
IrAM?An .alpha.2-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes
Original language description
We have cloned, sequenced and characterized an macromolecular protease inhibitor of ?2-macroglobulin family from the hard tick Ixodes ricinus named IrAM. Using the tool of RNA interference we have demonstrated that IrAM is an important constituent of tick innate immunity since it is involved in the phagocytosis of the pathogen Chryseobacterium indologenes by tick hemocytes. This is the first evidence showing that a cellular immune response in invertebrates is linked with interaction of an plasma ?2-macroglobulin with protease derived from invading pathogen.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Developmental and Comparative Immunology
ISSN
0145-305X
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
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UT code for WoS article
000263781100009
EID of the result in the Scopus database
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