Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00367199" target="_blank" >RIV/60077344:_____/11:00367199 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1159/000328851" target="_blank" >http://dx.doi.org/10.1159/000328851</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000328851" target="_blank" >10.1159/000328851</a>
Alternative languages
Result language
angličtina
Original language name
Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system
Original language description
Parasite survival inside the tick relies on the ability of a pathogen to escape or inhibit tick immune defenses, but the molecular interactions between the tick and its pathogens remain poorly understood. Here we report that tick genomes are unique in that they contain all known classes of the ?2-macroglobulin family (?2M-F) proteins: ?2-macroglobulin pan-protease inhibitors, C3 complement components, and insect thioester-containing and macroglobulin-related proteins. RNA interference-mediated gene silencing in the hard tick Ixodes ricinus revealed the central role of a C3-like molecule in the phagocytosis of bacteria and specific functions for ?2M-F proteins. Assessment of ?2M-F functions in a single organism should significantly contribute to the general knowledge on the evolution and function of the complement system. This publication was accomplished in co-operatin with Prof. Jules A. Hoffmann, the Nobel Prize laureate 2011 in Medicine and Physiology (see acknowledgements).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Innate Immunity
ISSN
1662-811X
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
623-630
UT code for WoS article
000296368900010
EID of the result in the Scopus database
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