Tick-borne encephalitis virus infection of cultured mouse macrophages

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00334900" target="_blank" >RIV/60077344:_____/09:00334900 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/09:00010477

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Tick-borne encephalitis virus infection of cultured mouse macrophages

Original language description

The interactions of tick-borne encephalitis virus (TBEV) with mouse macrophages were studied at electron microscopic level. The macrophages were sensitive to infection with TBEV strain Hypr (a highly neuroinvasive and neurovirulent strain for laboratorymice). However, these macrophage cells remained morphologically inactivated. Viral particles were located mainly in the ER. No virus production was observed in cells infected with the attenuated, non-neuroinvasive TBEV strain 263. In this case, the infection led to a clear morphological activation of the macrophages. The virus replication process in mouse macrophage cells might be different from that in other mammalian cell lines. Moreover, different TBEV strains exhibited a different interaction with the host macrophages. The inability of strain 263 to replicate in mouse macrophages as the first site of significant viral replication in vivo could be associated with the inability of this strain to establish a serious infection in mice.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Intervirology

ISSN

0300-5526

e-ISSN

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Volume of the periodical

52

Issue of the periodical within the volume

5

Country of publishing house

SZ - THE KINGDOM OF ESWATINI

Number of pages

8

Pages from-to

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UT code for WoS article

000269788600008

EID of the result in the Scopus database

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