The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00334921" target="_blank" >RIV/60077344:_____/09:00334921 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/09:00010453

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans

Original language description

Asymmetric cell divisions produce cells with distinct developmental fates, thus allowing differentiation of various tissues. Caenorhabditis elegans is extensively used to study cell fate determination, since its development relies heavily on asymmetric cell divisions. Differentiation of the epidermal cell T depends on its proper polarity that is established by the Wnt/.beta.-catenin asymmetry pathway. We show that the asymmetry of T cell division requires NHR-25, an evolutionarily conserved nuclear receptor. NHR-25 ensures the neural fate of the T cell lineage in cooperation with the Wnt/.beta.-catenin signaling. Loss of NHR-25 enhances the impact of mutated effectors of this pathway, POP-1/TCF and SYS-1/.beta.-catenin, on the T cell polarity, while itsuppresses the effect of the same mutations on asymmetric division of the somatic gonad precursor cells. Therefore, our findings define NHR-25 as a versatile modulator of Wnt/.beta.-catenin signaling to govern correct cell fate decision.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cell Science

ISSN

0021-9533

e-ISSN

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Volume of the periodical

122

Issue of the periodical within the volume

17

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

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UT code for WoS article

000269122000005

EID of the result in the Scopus database

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