Nuclear receptor NHR-25 interacts with Wnt/?-catenin signaling to direct differentiation of the C. elegans T cell
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00336504" target="_blank" >RIV/60077344:_____/09:00336504 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Nuclear receptor NHR-25 interacts with Wnt/?-catenin signaling to direct differentiation of the C. elegans T cell
Original language description
We show that an impaired function of the nuclear receptor NHR-25 abolishes differentiation of the neural T cell lineage similarly to mutations in Wnt/?-catenin asymmetry signaling pathwaycomponents. By means of genetic interactionwe demonstrate that NHR-25 cooperates with the Wnt/?-catenin pathway and with a parallel RUNX signaling to establish the correct fate of T cell daughters. Strikingly, the positive interaction between NHR-25 and Wnt/ catenin signaling in the T cell has an opposite character thanin the C. elegans somatic gonad, where NHR-25 was shown to antagonize a ?-catenin pathway.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů