Glycobiochemistry of ticks, vectors of infectious diseases: carbohydrate-binding proteins and glycans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00336484" target="_blank" >RIV/60077344:_____/09:00336484 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Glycobiochemistry of ticks, vectors of infectious diseases: carbohydrate-binding proteins and glycans
Original language description
The lectin IxoA and enzyme chitinase 1 are potential factors of innate immunity in I. ricinus, especially active against bacterial and fungal infections. We succesfully knock-down the genes for both IxoA and Chix1 by RNA inhibition. Hemolymph of IxoA knock-down ticks totally lost its hemagglutination activity and the function of both genes is further studied by RNAi. Glycoproteins and sialic acid (SA) in salivary glands (SG) of the tick Ixodes ricinus: SG in ticks are of fundamental significance for thepathogen transmission to the host, amongst others. We mapped the glycoproteins of tick SG, potential receptors for the transmitted pathogens. We identified SA in glycoproteome of SG as well as a protein binding this carbohydrate. Based on the molecularfeatures of the protein, it is similar to mouse sialoadhesin Siglec-1.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LC06009" target="_blank" >LC06009: Centre for molecular ecology of vectors and pathogens</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů