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Lyme disease transmission by severely impaired ticks

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00554652" target="_blank" >RIV/60077344:_____/22:00554652 - isvavai.cz</a>

  • Result on the web

    <a href="https://royalsocietypublishing.org/doi/10.1098/rsob.210244" target="_blank" >https://royalsocietypublishing.org/doi/10.1098/rsob.210244</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1098/rsob.210244" target="_blank" >10.1098/rsob.210244</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Lyme disease transmission by severely impaired ticks

  • Original language description

    It has been demonstrated that impairing protein synthesis using drugs targeted against tRNA amino acid synthetases presents a promising strategy for the treatment of a wide variety of parasitic diseases, including malaria and toxoplasmosis. This is the first study evaluating tRNA synthetases as potential drug targets in ticks. RNAi knock-down of all tested tRNA synthetases had a strong deleterious phenotype on Ixodes ricinus feeding. Our data indicate that tRNA synthetases represent attractive, anti-tick targets warranting the design of selective inhibitors. Further, we tested whether these severely impaired ticks were capable of transmitting Borrelia afzelii spirochaetes. Interestingly, biologically handicapped I. ricinus nymphs transmitted B. afzelii in a manner quantitatively sufficient to develop a systemic infection in mice. These data suggest that initial blood-feeding, despite the incapability of ticks to fully feed and salivate, is sufficient for activating B. afzelii from a dormant to an infectious mode, enabling transmission and dissemination in host tissues.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Open Biology

  • ISSN

    2046-2441

  • e-ISSN

    2046-2441

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    210244

  • UT code for WoS article

    000755243600001

  • EID of the result in the Scopus database

    2-s2.0-85124679913