Atick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00358349" target="_blank" >RIV/60077344:_____/11:00358349 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/11:00358349 RIV/60076658:12310/11:43882823
Result on the web
<a href="http://dx.doi.org/10.1182/blood-2010-06-293241" target="_blank" >http://dx.doi.org/10.1182/blood-2010-06-293241</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood-2010-06-293241" target="_blank" >10.1182/blood-2010-06-293241</a>

Result language
angličtina
Original language name
Atick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation
Original language description
A protein with antiinflammatory and anti-platelet effect was identified. It was named IRS-2 (Ixodes ricinus serpin ? 2). It belongs into the group of serpins ? inhibitors of serine proteases and the mode of action of IRS-2 derives from its inhibitory activity against cathepsin G and mast cell chymase. Antiinflammatory activity was shown using paw edema experiment with mice. IRS-2 inhibited specifically only cathepsin G and thrombin induced platelet aggregation.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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