Hemelipoglycoprotein from the ornate sheep tick, Dermacentor marginatus: structural and functional characterization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00359405" target="_blank" >RIV/60077344:_____/11:00359405 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/11:43876871

Result on the web

<a href="http://dx.doi.org/10.1186/1756-3305-4-4" target="_blank" >http://dx.doi.org/10.1186/1756-3305-4-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1756-3305-4-4" target="_blank" >10.1186/1756-3305-4-4</a>

Result language

angličtina

Original language name

Hemelipoglycoprotein from the ornate sheep tick, Dermacentor marginatus: structural and functional characterization

Original language description

Results: Hemelipoglycoprotein from sheep tick Dermacentor marginatus plasma was purified in native state by immunoprecipitation and denatured using electroelution from SDS-PAGE separated plasma. The protein (290 kDa) contains two subunits with molecularweights 100 and 95 kDa. It is glycosylated by high-mannose and complex N-glycans HexNAc(2)Hex(9), HexNAc(2)Hex(10), HexNAc(4)Hex(7), and HexNAc(4)Hex(8). The purified protein is able to agglutinate red blood cells and has galactose-and mannose-binding specificity. Feeding does not increase its amounts in male plasma. The hemelipoglycoprotein was detected also in hemocytes, salivary glands, and gut. In salivary glands, the protein was present in both glycosylated and nonglycosylated forms. In hemolymph,it is present in complexes with putative fibrinogen-related proteins. This, together with its carbohydrate-binding activity, suggests its possible involvement in tick innate immunity.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasites Vectors

ISSN

1756-3305

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

—

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

4

UT code for WoS article

000286388600001

EID of the result in the Scopus database

—