Telomore maintenance on organisms without telomerase

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00364291" target="_blank" >RIV/60077344:_____/11:00364291 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Telomore maintenance on organisms without telomerase
Original language description
Most eukaryotes elongate chromosome ends with telomerase that repeatedly adds copies of the short telomeric DNA sequence to the chromosome end. While there is strict conservation of telomeric sequence repeat in most species, the repeat unit has changed over evolutionary time. Lack of the predominant telomeric sequence in a species does not, however, signify that telomerase-generated terminal sequences are missing. Conversely, the presence of a canonical telomeric sequence does not necessarily indicate telomerase as a telomere maintenance mechanism. Although telomerase may have been the mechanism of telomere maintenance of the last common eukaryotic ancestor, it is not the only mechanism used to maintain chromosome length. Telomerase has been lost a fewtimes in the evolution of plants and animals. During insect evolution, for example, telomerase has been lost at least six times. Here, we discuss telomere maintenance mechanisms that replaced telomerase in telomere length maintenance.
Czech name
—
Czech description
—

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)