Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00364802" target="_blank" >RIV/60077344:_____/11:00364802 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/11:43872653

Result on the web

<a href="http://dx.doi.org/10.1016/j.pt.2011.02.003" target="_blank" >http://dx.doi.org/10.1016/j.pt.2011.02.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pt.2011.02.003" target="_blank" >10.1016/j.pt.2011.02.003</a>

Result language

angličtina

Original language name

Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors

Original language description

Trypanosome brucei undergoes two clearly distinct develomental stages: in the insect vector (procyclic stage) the cells generate the bulk of their energy through respiration, whereas in the bloodstream of the mammalian host (bloodstream stage) they growmostly glycolytically. Several mitochondrial respiratory proteins require iron-sulfur clusters for activity, and their activation coincides with developmental changes. Likewise some tRNA modification enzymes either require iron-sulfur clusters or use components of the iron-sulfur cluster assembly pathway for activity. These enzymes affect the anticodon loop of various tRNAs and can impact protein synthesis. Herein, the possibility of these pathways being integrated and exploited by T. brucei to carefully coordinate energy demands to translational rates in response to enviromental changes is examined.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Trends in Parasitology

ISSN

1471-4922

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

234-237

UT code for WoS article

000292238800003

EID of the result in the Scopus database

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