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Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00367346" target="_blank" >RIV/60077344:_____/11:00367346 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388963:_____/11:00367346

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.antiviral.2011.08.014" target="_blank" >http://dx.doi.org/10.1016/j.antiviral.2011.08.014</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.antiviral.2011.08.014" target="_blank" >10.1016/j.antiviral.2011.08.014</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants

  • Original language description

    The antiviral effect of the acyclic nucleoside phosphonate tenofovir (R)-PMPA on double-stranded DNA Cauliflower mosaic virus (CaMV) in Brassica pekinensis plants grown in vitro on liquid medium was evaluated. Double antibody sandwich ELISA and PCR wereused for relative quantification of viral protein and detecting nucleic acid in plants. (R)-PMPA at concentrations of 25 and 50 mg/l significantly reduced CaMV titers in plants within 6?9 weeks to levels detectable neither by ELISA nor by PCR. Virus-freeplants were obtained after 3-month cultivation of meristem tips on semisolid medium containing 50 mg/l (R)-PMPA and their regeneration to whole plants in the greenhouse. Studying the metabolism of (R)-PMPA in B. pekinensis revealed that mono- and diphosphate, structural analogs of NDP and/or NTP, are the only metabolites formed. The data indicate very low substrate activity of the enzymes toward (R)-PMPA as substrate.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA522%2F09%2F0707" target="_blank" >GA522/09/0707: Effect of acyclic nucleosid phosphonates and other antimetabolites against plant viruses</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Antiviral Research

  • ISSN

    0166-3542

  • e-ISSN

  • Volume of the periodical

    92

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    4

  • Pages from-to

    378-381

  • UT code for WoS article

    000297427200030

  • EID of the result in the Scopus database