Antiviral activity of acyclic nucleoside phosphonates PMEA, (S)-HPMPC, PMEDAP and ribavirin against Cauliflower mosaic virus in Brassica pekinensis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00377469" target="_blank" >RIV/60077344:_____/12:00377469 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/12:00377469

Result on the web

<a href="http://dx.doi.org/10.1007/s11240-012-0130-0" target="_blank" >http://dx.doi.org/10.1007/s11240-012-0130-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11240-012-0130-0" target="_blank" >10.1007/s11240-012-0130-0</a>

Result language

angličtina

Original language name

Antiviral activity of acyclic nucleoside phosphonates PMEA, (S)-HPMPC, PMEDAP and ribavirin against Cauliflower mosaic virus in Brassica pekinensis

Original language description

Antiviral effects of acyclic nucleoside phosphonates PMEA, (S)-HPMPC, PMEDAP, and ribavirin on double-stranded DNA Cauliflower mosaic virus (CaMV) were evaluated in Brassica pekinensis plants grown in vitro on liquid medium. A double-antibody sandwich ELISA was used for relative quantification of viral protein and PCR for detection of CaMV nucleic acid in plants. Ribavirin and PMEA had no significant antiviral effect. (S)-HPMPC at concentration 50 mg l -1 and PMEDAP at concentrations 50 and 12. 5 mg l -1 significantly (P < 0.05) reduced CaMV concentration in plants within 42-63 days to levels detectable neither by ELISA nor by PCR. A phytotoxicity experiment resulted in progressive yellowing of leaves and dwarfing in plants cultured 42 days on media with concentrations 12. 5, 25 and 50 mg l -1 of (S)-HPMPC and PMEDAP. Reduction in fresh and dry weights of plants was significant (P < 0. 05) already at 12. 5 mg l -1 with both compounds.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/GA522%2F09%2F0707" target="_blank" >GA522/09/0707: Effect of acyclic nucleosid phosphonates and other antimetabolites against plant viruses</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Plant Cell, Tissue and Organ Culture

ISSN

0167-6857

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

63-68

UT code for WoS article

000304664300007

EID of the result in the Scopus database

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