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Ligand-binding properties of a juvenile hormone receptor, Methoprene-tolerant

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00369355" target="_blank" >RIV/60077344:_____/11:00369355 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12310/11:43882689

  • Result on the web

    <a href="http://dx.doi.org/10.1073/pnas.1116123109" target="_blank" >http://dx.doi.org/10.1073/pnas.1116123109</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1073/pnas.1116123109" target="_blank" >10.1073/pnas.1116123109</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Ligand-binding properties of a juvenile hormone receptor, Methoprene-tolerant

  • Original language description

    Juvenile hormone (JH) is a terpenoid, a small lipophilic molecule of vital importance to insects. The molecular action of JH has for long decades remained an enigma, because a JH receptor could not be identified. In this study we provide conclusive evidence for the JH receptor role of the bHLH-PAS domain transcription factor Methoprene-tolerant (Met). By testing Met point mutant proteins in vitro, we determined specific amino acids contributing to the high-affinity JH binding. Using mutants unable to bind JH, we demonstrated that interactions of Met with partner proteins require the ligand-binding capacity of Met. Therefore, Met resembles certain nuclear receptors, e. g., of retinoic acid or thyroid hormone, but since Met belongs to a different proteinfamily, it establishes a prototype of a hormonal receptor of a novel class. Our results address a long-standing question of the mechanism of action of juvenile hormone and its insecticidal analogs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Proceedings of the National Academy of Sciences of the United States of America

  • ISSN

    0027-8424

  • e-ISSN

  • Volume of the periodical

    108

  • Issue of the periodical within the volume

    52

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    21128-21133

  • UT code for WoS article

    000298479900054

  • EID of the result in the Scopus database