Chromatin modification of Notch targets in olfactory receptor neuron diversification

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00375133" target="_blank" >RIV/60077344:_____/12:00375133 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/12:43882751

Result on the web

<a href="http://dx.doi.org/10.1038/nn.2998" target="_blank" >http://dx.doi.org/10.1038/nn.2998</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nn.2998" target="_blank" >10.1038/nn.2998</a>

Result language

angličtina

Original language name

Chromatin modification of Notch targets in olfactory receptor neuron diversification

Original language description

Neuronal-class diversification is central during neurogenesis. This requirement is exemplified in the olfactory system, which utilizes a large array of olfactory receptor neuron (ORN) classes. We discovered an epigenetic mechanism in which neuron diversity is maximized via locus-specific chromatin modifications that generate context-dependent responses from a single, generally used intracellular signal. Each ORN in Drosophila acquires one of three basic identities defined by the compound outcome of three iterated Notch signaling events during neurogenesis. Hamlet, the Drosophila Evi1 and Prdm16 proto-oncogene homolog, modifies cellular responses to these iteratively used Notch signals in a context-dependent manner, and controls odorant receptor gene choice and ORN axon targeting specificity. In nascent ORNs, Hamlet erases the Notch state inherited from the parental cell, enabling a modified response in a subsequent round of Notch signaling. Hamlet directs locus-specific modifications o

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Neuroscience

ISSN

1097-6256

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

224-233

UT code for WoS article

000299603500013

EID of the result in the Scopus database

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