Adaptive integrate-and-fire model reproduces the dynamics of olfactory receptor neuron responses in a moth
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00509159" target="_blank" >RIV/67985823:_____/19:00509159 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1098/rsif.2019.0246" target="_blank" >https://doi.org/10.1098/rsif.2019.0246</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1098/rsif.2019.0246" target="_blank" >10.1098/rsif.2019.0246</a>
Alternative languages
Result language
angličtina
Original language name
Adaptive integrate-and-fire model reproduces the dynamics of olfactory receptor neuron responses in a moth
Original language description
In order to understand how olfactory stimuli are encoded and processed in the brain, it is important to build a computational model for olfactory receptor neurons (ORNs). Here, we present a simple and reliable mathematical model of a moth ORN generating spikes. The model incorporates a simplified description of the chemical kinetics leading to olfactory receptor activation and action potential generation. We show that an adaptive spike threshold regulated by prior spike history is an effective mechanism for reproducing the typical phasic–tonic time course of ORN responses. Our model reproduces the response dynamics of individual neurons to a fluctuating stimulus that approximates odorant fluctuations in nature. The parameters of the spike threshold are essential for reproducing the response heterogeneity in ORNs. The model provides a valuable tool for efficient simulations of olfactory circuits.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10102 - Applied mathematics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the Royal Society Interface
ISSN
1742-5689
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
157
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
20190246
UT code for WoS article
000484404700017
EID of the result in the Scopus database
2-s2.0-85071152766