Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00375992" target="_blank" >RIV/60077344:_____/12:00375992 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1365-3024.2011.01345.x" target="_blank" >http://dx.doi.org/10.1111/j.1365-3024.2011.01345.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1365-3024.2011.01345.x" target="_blank" >10.1111/j.1365-3024.2011.01345.x</a>

Result language
angličtina
Original language name
Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection
Original language description
Type I interferons (IFN-a and IFN-beta) are crucial determinants of the host immune response and tick saliva modulates this response, thus facilitating the transmission of tickborne pathogens. The current study therefore examines the effect of Ixodes ricinus tick saliva on IFN-beta signalling in murine dendritic cells using lipopolysaccharide (LPS) and Borrelia afzelii spirochaetes as inducers. Our results show that Borrelia-induced activation of STAT-1 was suppressed by tick saliva. Our data indicate that similar to I. ricinus tick saliva may modulate the host immune response by attenuating the initial signal transduction pathway of type I IFN.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/LC06009" target="_blank" >LC06009: Centre for molecular ecology of vectors and pathogens</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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