Effect of tick saliva on signalling pathways activated by TLR-2 ligand and Borrelia afzelii in dendritic cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00387477" target="_blank" >RIV/60077344:_____/12:00387477 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2012.01375.x/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2012.01375.x/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1365-3024.2011.01345.x" target="_blank" >10.1111/j.1365-3024.2011.01345.x</a>

Result language

angličtina

Original language name

Effect of tick saliva on signalling pathways activated by TLR-2 ligand and Borrelia afzelii in dendritic cells

Original language description

Dendritic cells are a sentinel in defending against pathogens and tick saliva facilitates transmission of tick-borne pathogens by modulating the host immune response. The maturation of dendritic cells is inhibited by tick saliva. To elucidate the mechanism of this inhibition, we tested the impact of Ixodes ricinus tick saliva on signalling pathways activated by Toll-like receptor (TLR-2) ligand and Borrelia afzelii in spleen dendritic cells. The activation of nuclear factor-jB (NF-jB) p65 and phosphatidylinositol-3 kinase (PI3K)/ Akt pathways was decreased by tick saliva upon both TLR- 2 and Borrelia stimulation. Among the mitogen-activated protein kinases (MAPK), the activation of extracellular matrix-regulated kinase (Erk1/ 2) was suppressed by ticksaliva, but not p38. In response to spirochaetes, the amount of TNF-a decreased in the presence of tick saliva which was mediated by selective suppression of Erk1/ 2, NF-jB and Akt as tick saliva mimicked the effect of their specific inhi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasite immunology

ISSN

0141-9838

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

8-9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

421-429

UT code for WoS article

000307105500004

EID of the result in the Scopus database

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