Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00453397" target="_blank" >RIV/60077344:_____/15:00453397 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/15:43888811

Result on the web

<a href="http://dx.doi.org/10.1186/s13071-015-0887-1" target="_blank" >http://dx.doi.org/10.1186/s13071-015-0887-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13071-015-0887-1" target="_blank" >10.1186/s13071-015-0887-1</a>

Result language

angličtina

Original language name

Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes

Original language description

We determined the effect of cystatins on the production of chemokines in Borrelia-infected bone-marrow derived DC. The production of MIP-1 alpha was severely suppressed by both cystatins, while IP-10 was selectively inhibited only by Sialo L2. As TLR-2 is a major receptor activated by Borrelia spirochetes, we tested whether cystatins influence signalling pathways activated by TLR-2 ligand, lipoteichoic acid (LTA). Sialo L2 and weakly Sialo L attenuated the extracellular matrix-regulated kinase (Erk1/2)pathway. The activation of phosphatidylinositol-3 kinase (PI3K)/Akt pathway and nuclear factor-kappa B (NF-kappa B) was decreased only by Sialo L2. In response to Borrelia burgdorferi, the activation of Erk1/2 was impaired by Sialo L2. Production of IFN-beta was analysed in plasmacytoid DC exposed to Borrelia, TLR-7, and TLR-9 ligands. Sialo L, in contrast to Sialo L2, decreased the production of IFN-beta in pDC and also impaired the maturation of these cells.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasites Vectors

ISSN

1756-3305

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

MAY 15 2015

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

000354848900001

EID of the result in the Scopus database

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