Tick salivary cystatin sialostatin L2 suppresses IFN responses in mouse dendritic cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00453400" target="_blank" >RIV/60077344:_____/15:00453400 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/15:43888810

Result on the web

<a href="http://dx.doi.org/10.1111/pim.12162" target="_blank" >http://dx.doi.org/10.1111/pim.12162</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/pim.12162" target="_blank" >10.1111/pim.12162</a>

Result language

angličtina

Original language name

Tick salivary cystatin sialostatin L2 suppresses IFN responses in mouse dendritic cells

Original language description

Type I interferon (IFN), mainly produced by dendritic cells (DCs), is critical in the host defence against tick-transmitted pathogens. Here, we report that salivary cysteine protease inhibitor from the hard tick Ixodes scapularis, sialostatin L2, affectsIFN- mediated immune reactions in mouse dendritic cells. Following IFN receptor ligation, the Janus activated kinases/signal transducer and activator of transcription (JAK/STAT) pathway is activated. We show that sialostatin L2 attenuates phosphorylation of STATs in spleen dendritic cells upon addition of recombinant IFN-. LPS-stimulated dendritic cells release IFN- which in turn leads to the induction of IFN-stimulated genes (ISG) through JAK/STAT pathway activation. The induction of two ISG, interferon regulatory factor 7 (IRF-7) and IP-10, was suppressed by sialostatin L2 in LPS-stimulated dendritic cells. Finally, the interference of sialostatin L2 with IFN action led to the enhanced replication of tick-borne encephalitis virus in

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasite immunology

ISSN

0141-9838

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

70-78

UT code for WoS article

000348718100002

EID of the result in the Scopus database

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