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Differential response of Drosophila cell lines to extracellular adenosine

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00376113" target="_blank" >RIV/60077344:_____/12:00376113 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12310/12:43883567

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0965174812000033" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0965174812000033</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ibmb.2012.01.002" target="_blank" >10.1016/j.ibmb.2012.01.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Differential response of Drosophila cell lines to extracellular adenosine

  • Original language description

    Adenosine (Ado) is a crucial metabolite that influences proliferation of several vertebrate and invertebrate cells. Key proteins regulating Ado signaling, transport and metabolism are conserved among vertebrates and invertebrates. Here we show that Ado negatively influences viability, changes morphology and mitochondrial polarity of the Drosophila imaginal disc cell line (Cl.8ţ) via a mechanism exclusively dependent on cellular Ado uptake. High transport of Ado is followed by ATP production as a part ofAdo salvation, which at higher concentrations may interfere with cellular homeostasis. In contrast, hematopoietic cell line Mbn2, which grows well in high Ado concentration, preferentially uses adenosine deaminase as a part of the purine catabolic pathway. Our results show that different types of Drosophila cell lines use different pathways for Ado conversion and suggest that such differences may be an important part of complex mechanisms maintaining energy homeostasis in the body.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Insect Biochemistry and Molecular Biology

  • ISSN

    0965-1748

  • e-ISSN

  • Volume of the periodical

    42

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

    321-331

  • UT code for WoS article

    000302515800002

  • EID of the result in the Scopus database