Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00438115" target="_blank" >RIV/60077344:_____/15:00438115 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/15:43890324
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs11302-014-9435-2" target="_blank" >http://link.springer.com/article/10.1007%2Fs11302-014-9435-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11302-014-9435-2" target="_blank" >10.1007/s11302-014-9435-2</a>

Result language
angličtina
Original language name
Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies
Original language description
Adenosine (Ado) is a purine nucleoside that modulates many physiological processes in the body. It plays a prominent role as a paracrine signal of metabolic imbalance within tissues and serves as a signaling mechanism to coordinate tissue activity. Ado exerts a broad range of cytoprotective, growth-promoting, and immunosuppressive effects and was observed at a high concentration in a number of human tumors, it was therefore suggested to be an important factor regulating tumor growth. We developed a method for the measurement of the Ado effect on tumor growth in/Drosophila melanogaster/using the modification of somatic mutation and recombination test (SMART). In this report, we examined the effect of three/Drosophila/genes involved in Ado signaling on the incidence of somatic mosaic clones, including adenosine receptor (/AdoR/), adenosine transporter (/Ent2/), and adenosine deaminase/Adgf-A/. We show that genetic manipulations with these genes do not affect control clones, but cause dra
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/GA14-27816S" target="_blank" >GA14-27816S: Functions of adenosine signaling in organism</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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