Evolution of Fe/S cluster biogenesis in the anaerobic parasite Blastocystis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00378838" target="_blank" >RIV/60077344:_____/12:00378838 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/12:43883515
Result on the web
<a href="http://dx.doi.org/10.1073/pnas.1116067109" target="_blank" >http://dx.doi.org/10.1073/pnas.1116067109</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1116067109" target="_blank" >10.1073/pnas.1116067109</a>
Alternative languages
Result language
angličtina
Original language name
Evolution of Fe/S cluster biogenesis in the anaerobic parasite Blastocystis
Original language description
Iron/sulfur cluster (ISC)-containing proteins are essential components of cells. In most eukaryotes, Fe/S clusters are synthesized by the mitochondrial ISC machinery, the cytosolic iron/sulfur assembly system, and, in photosynthetic species, a plastid sulfur-mobilization (SUF) system. Here we show that the anaerobic human protozoan parasite Blastocystis, in addition to possessing ISC and iron/sulfur assembly systems, expresses a fused version of the SufC and SufB proteins of prokaryotes that it has acquired by lateral transfer from an archaeon related to the Methanomicrobiales, an important lineage represented in the human gastrointestinal tract microbiome. Although components of the Blastocystis ISC system function within its anaerobic mitochondrion-related organelles and can functionally replace homologues in Trypanosoma brucei, its SufCB protein has similar biochemical properties to its prokaryotic homologues, functions within the parasite's cytosol, and is up-regulated under oxygen
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
109
Issue of the periodical within the volume
26
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
10426-10431
UT code for WoS article
000306291400069
EID of the result in the Scopus database
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