Metabolic sensors and their interplay with cell signalling and transcription

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00384133" target="_blank" >RIV/60077344:_____/12:00384133 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/12:43883959

Result on the web

<a href="http://www.biochemsoctrans.org/bst/040/0311/0400311.pdf" target="_blank" >http://www.biochemsoctrans.org/bst/040/0311/0400311.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1042/BST20110767" target="_blank" >10.1042/BST20110767</a>

Result language

angličtina

Original language name

Metabolic sensors and their interplay with cell signalling and transcription

Original language description

There is an intimate, yet poorly understood, link between cellular metabolic status, cell signalling and transcription.Central metabolic pathways are under the control of signalling pathways and, vice versa, cellular metabolic profile influences cell signalling through the incorporation of various metabolic sensors into the signalling networks. Thus information about nutrients availability directly and crucially influences crucial cell decisions. In the present review, I summarize our current knowledgeof various metabolic sensors and give some examples of the integration of metabolically derived inputs into the signalling system and the regulation of transcription. I also discuss the Warburg effect where the cross-talk between metabolism and signalling is used to orchestrate rapid cell growth and division. It is becoming clear that future research will concentrate on the collection of small-molecule metabolites, whose concentration fluctuates in response to cellular energy levels, sea

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GAP305%2F11%2F0126" target="_blank" >GAP305/11/0126: Notch signalling at the context of cellular metabolism.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemical Society Transactions

ISSN

0300-5127

e-ISSN

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Volume of the periodical

40

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

311-323

UT code for WoS article

000303624200002

EID of the result in the Scopus database

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