Make It, Take It, or Leave It: Heme Metabolism of Parasites

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00392770" target="_blank" >RIV/60077344:_____/13:00392770 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/13:43885044

Result on the web

<a href="http://dx.doi.org/10.1371/journal.ppat.1003088" target="_blank" >http://dx.doi.org/10.1371/journal.ppat.1003088</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.ppat.1003088" target="_blank" >10.1371/journal.ppat.1003088</a>

Result language

angličtina

Original language name

Make It, Take It, or Leave It: Heme Metabolism of Parasites

Original language description

Heme and other tetrapyrroles, often called ?the colors of life, belong to the most important molecules of almost all extant organisms. They are synthesized by a common multistep pathway that is highly conserved throughout the tree of life [1]. One of thetetrapyrrole products is chlorophyll, the green pigment of plants and other phototrophs, which captures the energy of the sun. Vitamin B12, the most complex tetrapyrrole, is involved in DNA synthesis and energy metabolism [2]. The major product of tetrapyrrole biosynthesis in non-photosynthetic organisms is heme, an iron-coordinated porphyrin with the capacity to transfer electrons and bind diatomic gases. Here we summarize the current understanding of different aspects of heme metabolism in parasiticeukaryotes, including the synthesis and uptake of heme and its detoxification. A differential need for heme in distinct parasitic groups and the suitability of heme metabolism as a drug target for treating parasite-borne diseases are also

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GAP305%2F11%2F2179" target="_blank" >GAP305/11/2179: Characterization of Fe-S cluster assembly in Trypanosoma brucei</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Plos Pathogens

ISSN

1553-7374

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

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UT code for WoS article

000314464600008

EID of the result in the Scopus database

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