Both human ferredoxins equally efficiently rescue ferredoxin deficiency in Trypanosoma brucei
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00396398" target="_blank" >RIV/60077344:_____/13:00396398 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/13:43885293
Result on the web
<a href="http://dx.doi.org/10.1111/mmi.12264" target="_blank" >http://dx.doi.org/10.1111/mmi.12264</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/mmi.12264" target="_blank" >10.1111/mmi.12264</a>
Alternative languages
Result language
angličtina
Original language name
Both human ferredoxins equally efficiently rescue ferredoxin deficiency in Trypanosoma brucei
Original language description
Ferredoxins are highly conserved proteins that function universally as electron transporters. They not only require Fe-S clusters for their own activity, but are also involved in Fe-S formation itself. We identified two homologues of ferredoxin in the genome of the parasitic protist Trypanosoma brucei and named them TbFdxA and TbFdxB. TbFdxA protein, which is homologous to other eukaryotic mitochondrial ferredoxins, is essential in both the procyclic (=insect-transmitted) and bloodstream (mammalian) stage, but is more abundant in the active mitochondrion of the former stage. Depletion of TbFdxA caused disruption of Fe-S cluster biogenesis and lowered the level of intracellular haem. However, TbFdxB, which is present exclusively within kinetoplastid flagellates, was non-essential for the procyclic stage, and double knock-down with TbFdxA showed this was not due to functional redundancy between the two homologues. Heterologous expressions of human orthologues HsFdx1 and HsFdx2 fully resc
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Microbiology
ISSN
0950-382X
e-ISSN
—
Volume of the periodical
89
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
135-151
UT code for WoS article
000320728800010
EID of the result in the Scopus database
—