Effects of Aedes aegypti salivary components on dendritic cell and lymphocyte biology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00420947" target="_blank" >RIV/60077344:_____/13:00420947 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/1756-3305-6-329" target="_blank" >http://dx.doi.org/10.1186/1756-3305-6-329</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1756-3305-6-329" target="_blank" >10.1186/1756-3305-6-329</a>

Result language

angličtina

Original language name

Effects of Aedes aegypti salivary components on dendritic cell and lymphocyte biology

Original language description

Saliva is a key element of interaction between hematophagous mosquitoes and their vertebrate hosts. In addition to allowing a successful blood meal by neutralizing or delaying hemostatic responses, the salivary cocktail is also able to modulate the effector mechanisms of host immune responses facilitating, in turn, the transmission of several types of microorganisms. Understanding how the mosquito uses its salivary components to circumvent host immunity might help to clarify the mechanisms of transmission of such pathogens and disease establishment. Flow cytometry was used to evaluate if increasing concentrations of A. aegypti salivary gland extract (SGE) affects bone marrow-derived DC differentiation and maturation. Lymphocyte proliferation in the presence of SGE was estimated by a colorimetric assay. Western blot and Annexin V staining assays were used to assess apoptosis in these cells. Naive and memory cells from mosquito-bite exposed mice or OVA-immunized mice and their respective

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasites Vectors

ISSN

1756-3305

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

NOV 2013

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

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UT code for WoS article

000328833800001

EID of the result in the Scopus database

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