The variability of the large genomic segment of Tahyna orthobunyavirus and an all-atom exploration of its anti-viral drug resistance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00420965" target="_blank" >RIV/60077344:_____/13:00420965 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/13:43885532 RIV/00027162:_____/13:#0001055

Result on the web

<a href="http://dx.doi.org/10.1016/j.meegid.2013.09.023" target="_blank" >http://dx.doi.org/10.1016/j.meegid.2013.09.023</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.meegid.2013.09.023" target="_blank" >10.1016/j.meegid.2013.09.023</a>

Result language

angličtina

Original language name

The variability of the large genomic segment of Tahyna orthobunyavirus and an all-atom exploration of its anti-viral drug resistance

Original language description

Tahyna virus (TAHV), a member of the Bunyaviridae family (California complex), is an important but neglected human mosquito-borne pathogen. The virus genome is composed of three segments, i.e., small (S), medium (M), and large (L). Previous studies on genetic variability of viruses within the California complex were focused on S and M segments, but the L segment remains relatively unstudied. To assess the genetic variation and the relation to virus phenotype we analyzed the L segment sequences of biologically diverse TAHV strains isolated in the Czech Republic and Slovakia. Phylogenetic analysis covering all available sequences of the L segment of TAHV clearly revealed two distinguished lineages, tentatively named as "European" and "Asian". The L segment strains within the European lineage are highly conserved (identity 99.3%), whilst Asian strains are more genetically diverse (identity 97%). Based on sequence comparison with other bunyaviruses, several non-synonymous nucleotide substi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Infection, Genetics and Evolution

ISSN

1567-1348

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

2013-Dec

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

304-311

UT code for WoS article

000327701200039

EID of the result in the Scopus database

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