The T. brucei TRM5 methyltransferase plays an essential role in mitochondrial protein synthesis and function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00420979" target="_blank" >RIV/60077344:_____/13:00420979 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/13:43885294

Result on the web

<a href="http://dx.doi.org/10.1261/rna.036665.112" target="_blank" >http://dx.doi.org/10.1261/rna.036665.112</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1261/rna.036665.112" target="_blank" >10.1261/rna.036665.112</a>

Result language

angličtina

Original language name

The T. brucei TRM5 methyltransferase plays an essential role in mitochondrial protein synthesis and function

Original language description

All tRNAs undergo post-transcriptional chemical modifications as part of their natural maturation pathway. Some modifications, especially those in the anticodon loop, play important functions in translational efficiency and fidelity. Among these, 1-methylguanosine, at position 37 (m(1)G(37)) of the anticodon loop in several tRNAs, is evolutionarily conserved and participates in translational reading frame maintenance. In eukaryotes, the tRNA methyltransferase TRM5 is responsible for m(1)G formation in nucleus-encoded as well as mitochondria-encoded tRNAs, reflecting the universal importance of this modification for protein synthesis. However, it is not clear what role, if any, mitochondrial TRM5 serves in organisms that do not encode tRNAs in their mitochondrial genomes. These organisms may easily satisfy the m(1)G(37) requirement through their robust mitochondrial tRNA import mechanisms. We have explored this possibility in the parasitic protist Trypanosoma brucei and show that down-r

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

R N A

ISSN

1355-8382

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

649-658

UT code for WoS article

000317584100007

EID of the result in the Scopus database

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