A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00421240" target="_blank" >RIV/60077344:_____/13:00421240 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3389/fmicb.2013.00308" target="_blank" >http://dx.doi.org/10.3389/fmicb.2013.00308</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmicb.2013.00308" target="_blank" >10.3389/fmicb.2013.00308</a>

Result language

angličtina

Original language name

A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva

Original language description

Arthropod saliva possesses anti-hemostatic, anesthetic, and anti-inflammatory properties that facilitate feeding and, inadvertently, dissemination of pathogens. Vector-borne diseases caused by these pathogens affect millions of people each year. Many studies address the impact of arthropod salivary proteins on various immunological components. However, whether and how arthropod saliva counters Nod-like (NLR) sensing remains elusive. NLRs are innate immune pattern recognition molecules involved in detecting microbial molecules and danger signals. Nod1/2 signaling results in activation of the nuclear factor-?B and the mitogen-activated protein kinase pathways. Caspase-1 NLRs regulate the inflammasome- a protein scaffold that governs the maturation of interleukin (IL)-1? and IL-18. Recently, several vector-borne pathogens have been shown to induce NLR activation in immune cells. Here, we provide a brief overview of NLR signaling and discuss clinically relevant vector-borne pathogens recog

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Microbiolgy

ISSN

1664-302X

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

OCT 2013

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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