Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microDNA
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00422599" target="_blank" >RIV/60077344:_____/13:00422599 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1534/genetics.113.153585" target="_blank" >http://dx.doi.org/10.1534/genetics.113.153585</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1534/genetics.113.153585" target="_blank" >10.1534/genetics.113.153585</a>
Alternative languages
Result language
angličtina
Original language name
Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microDNA
Original language description
The first microRNAs were discovered some 20 years ago, but only a small fraction of the microRNA-encoding genes have been described in detail yet. Here we report the molecular analysis of a computationally predicted Drosophila melanogaster microRNA gene,mir-282. We show that the mir-282 gene is the source of a 4.9-kb-long primary transcript with a 5' cap and a 3'-poly(A) sequence and a mature microRNA of similar to 25 bp. Our data strongly suggest the existence of an independent mir-282 gene conservedin holometabolic insects. We give evidence that the mir-282 locus encodes a functional transcript that influences viability, longevity, and egg production in Drosophila. We identify the nervous system-specific adenylate cyclase (rutabaga) as a target ofmiR-282 and assume that one of the main functions of mir-282 is the regulation of adenylate cyclase activity in the nervous system during metamorphosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genetics
ISSN
0016-6731
e-ISSN
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Volume of the periodical
195
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
469-480
UT code for WoS article
000325286200016
EID of the result in the Scopus database
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