The majority of sialylated glycoproteins in adult Ixodes ricinus ticks originate in the host, not the tick

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00430608" target="_blank" >RIV/60077344:_____/14:00430608 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/14:43887334
Result on the web
<a href="http://dx.doi.org/10.1016/j.carres.2014.02.017" target="_blank" >http://dx.doi.org/10.1016/j.carres.2014.02.017</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carres.2014.02.017" target="_blank" >10.1016/j.carres.2014.02.017</a>

Result language
angličtina
Original language name
The majority of sialylated glycoproteins in adult Ixodes ricinus ticks originate in the host, not the tick
Original language description
The presence of sialylated structures in tick organs was observed previously using lectin staining. Recently, we demonstrated the presence of sialylated N-glycans using mass spectrometry in tick salivary glands and the gut. However, we proposed a host (blood) origin for these glycans and mapped the transport of sialylated molecules from the gut to the salivary glands. In this report, we performed quantitation of whole sialic acid and of metabolically incorporated sialic acid (N-azido neuraminic acid) inIxodes ricinus tick samples. We show that the majority of sialylated molecules in the adult tick originate in the host (blood) and are not synthesized by the tick. Similar results were observed for tick cell cultures. The almost complete absence of ticksialylated molecules and the specific transport and localization of host structures into the tick salivary glands and the saliva raises many questions on the role of these molecules in the physiology and, specifically, the blood-feeding
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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